The game uses a 55-card deck that contains one 1, two 2s, three 3s, and so on up to ten 10s. At the start of the game, shuffle the deck, then remove five cards from play unseen. Deal one card face-up to each player. Whoever has the lowest card is the first active player. She decides whether to "hit" that is, be dealt another card or forfeit the round. If she hits and is dealt a card that doesn't match a card she already has in front of her, then the next player clockwise becomes the active player; if the card does match, then the round ends, she keeps one of these matching cards as penalty points, then everyone else discards their cards and a new round begins with each player being dealt a card. If the active player forfeits, the round ends and she takes the lowest-valued card visible on the table as penalty points, then a new round begins. Penalty cards remain set aside, even if the deck is shuffled to continue play. If a player acquires more penalty points than the predetermined threshold, then the game ends and this player loses. (Alternatively, players can use coins to track scores between games, with the loser paying everyone one coin, paying her score in coins to the player with the lowest score, etc.) There are many versions of Pairs from Cheapass Games. The base game play is identical, but the artwork (and artist) vary across the versions. Some include special game rules relevant to the theme of the deck.

• PRESS YOUR LUCK in this simple card game where there are no winners, but one loser. This deck also contains the absurd bidding game Venture.
• CARD CHARACTERS: The deck features the Professor and his many friends and enemies, including Sadie Bell, Geoffrey his orangutan butler, and the terrifying Badgermingo.
• THEMED ARTWORK: Features cards with art unique to this deck's theme. The Professor Elemental deck is a collaboration between artist Cheyenne Wright and real-life chap-hop artist Professor Elemental.
• AVOID PAIRS of numbers in order to avoid being the loser. Deal cards to your friends and hope for a match of their cards.
• THEMED FUN: All sorts of fun to be had with this simple, fast, and fun pub game!